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Pirfenidone is used in the treatment of mild to moderate Idiopathic PulmonaryFibrosis (IPF). IPF is chronic fibrotic and inflammatory lung disease where the lungs tissues become swollen and scarred over time due to synthesis and release of certain chemicals (pro-inflammatory cytokines such as tumor necrosis factor-alpha [TNF] and interleukin-1-beta [IL-1]), causing difficulty in breathing.
How it works:
Pirfenidone is an anti-fibrotic and anti-inflammatory agent and belongs to a class of medications called pyridones. Pirfenidone relieves conditions of idiopathic pulmonary fibrosis by reducing fibroblast growth (cells of the connective tissue which produce collagen and other fibres), reducing production of inflammatory chemicals and preventing accumulation of cell contents (extracellular matrix), thereby relieving swelling and inflammation of the lungs.